Clinical and radiologic reversal of stroke-like episodes in MELAS with high-dose L-arginine.
نویسندگان
چکیده
144 Memory, executive, and multidomain subtle cognitive impairment: Clinical and biomarker findings J.B. Toledo, M. Bjerke, K. Chen, M. Rozycki, C.R. Jack, Jr, M.W. Weiner, S.E. Arnold, E.M. Reiman, C. Davatzikos, L.M. Shaw, and J.Q. Trojanowski, for the Alzheimer’s Disease Neuroimaging Initiative 154 Kidney function and microstructural integrity of brain white matter S. Sedaghat, L.G.M. Cremers, M. de Groot, E.J. Hoorn, A.Hofman, A. vander Lugt,O.H. Franco,M.W.Vernooij, A. Dehghan, and M.A. Ikram
منابع مشابه
Stroke in MELAS is a Vasogenic Edema and Not Ischemic
We read with interest the article by Almasi et al. on a 48 years old female patient with Mitochondrial Encephalomyopathy, Lactic Acidosis, And Stroke-like episodes (MELAS), diagnosed based on the clinical presentation, blood test results, and imaging and muscle biopsy findings . We have the following comments and concerns.
متن کاملEffect of long-term oral treatment with L-arginine and idebenone on the prevention of stroke-like episodes in an adult MELAS patient.
INTRODUCTION Mitochondrial encephalopathy, lactic acidosis and stroke-like episodes (MELAS) is a maternally-inherited multisystem disorder. Mitochondrial angiopathy mediated by nitric oxide, a metabolite of L-arginine, is among the proposed pathophysiologic mechanisms of stroke-like episodes (SLEs) in MELAS. There are very few reports on long-term prevention of SLEs with oral L-arginine and ide...
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Introduction: Mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) can involve multiple systems and cause stroke-like episodes and status epilepticus. Case Presentation: A 48-year-old female with history of early fatigability, migraine-type headaches, and bilateral sensory-neural hearing loss presented 3 episodes of serial seizures. On admission she was affected by W...
متن کامل18F-FDG PET/CT findings in a possible MELAS syndrome: A case study
Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome is a rare congenital disorder of mitochondrial DNA, presenting a wide range of clinical symptoms comprising headaches, seizures, aphasia, hearing loss, visual defects, and hemiparesis. Herein we report a case of a previously asymptomatic 40-year-old male who presented with recurrent headache, seiz...
متن کاملL-Arginine Affects Aerobic Capacity and Muscle Metabolism in MELAS (Mitochondrial Encephalomyopathy, Lactic Acidosis and Stroke-Like Episodes) Syndrome.
OBJECTIVE To study the effects of L-arginine (L-Arg) on total body aerobic capacity and muscle metabolism as assessed by (31)Phosphorus Magnetic Resonance Spectroscopy ((31)P-MRS) in patients with MELAS (Mitochondrial Encephalomyopathy with Lactic Acidosis and Stroke-like episodes) syndrome. METHODS We performed a case control study in 3 MELAS siblings (m.3243A>G tRNA(leu(UUR)) in MTTL1 gene)...
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ورودعنوان ژورنال:
- Neurology
دوره 85 2 شماره
صفحات -
تاریخ انتشار 2015